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- W2368231561 abstract "[Purpose] To explore the role of hMLH1 and p53 gene in the carcinogenesis of sporadic colorectal carcinoma.[Methods] The expression of hMLH1 and p53 protein in 60 cases with sporadic colorectal carcinoma,45 cases with colorectal adenoma and 26 cases with normal intestinal mucosa were detected by PV-6000 immunohistochemical method.[Results](1)Negative expression of hMLH1 protein and positive expression of p53 protein were detected in 11 cases(18.3%)and 32 cases(53.3%)with sporadic colorectal carcinoma respectively.Negative expression of hMLH1 protein and positive expression of p53 protein were closely related to patient's age,tumor location,histological type and histological grade(P0.05 or P0.01),but were not correlated with patient's gender,tumor gross type,tumor size,invasive depth,lymph node metastasis,distant metastasis and Duke's stage(P0.05).(2)The positive expression of p53 protein was closely related to adenoma site,histological type and dysplasia grade,but it was not correlated with patient's gender and age(P0.05).(3)The positive expression of p53 protein in the group of hMLH1 protein negative expression(18.2%,2/11)was lower than that in the group of hMLH1 protein positive expression(61.2%,30/49)in sporadic colorectal carcinoma(P0.05).[Conclusions](1)Majority of sporadic colorectal carcinoma occurs via the chromosomal instability pathway in which the p53 gene plays an important role,meanwhile there is a subset of sporadic colorectal carcinoma displaying mismatch repair(MMR)defect with specially clinical and pathological features.(2)There is a subset of colorectal adenoma displaying negative expression of hMLH1 protein and positive expression of p53 protein.Mutation of hMLH1 gene and p53 gene may be an early event of carcinogenesis in sporadic colorectal carcinoma." @default.
- W2368231561 created "2016-06-24" @default.
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- W2368231561 date "2007-01-01" @default.
- W2368231561 modified "2023-09-23" @default.
- W2368231561 title "Expression of hMLH1 and p53 in Sporadic Colorectal Carcinoma and Colorectal Adenoma" @default.
- W2368231561 hasPublicationYear "2007" @default.
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