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- W2368241926 abstract "OBJECTIVE To investigate the changes in polymorphonuclear neutrophil(PMN) apoptosis and Fas,Bcl-2 protein expression of pediatric patients undergoing open-heart surgery with ECC,and to give the experimental basis for treating systemic inflammatory reaction syndrome(SIRS).METHODS Thirty pediatric patients with ventricular septal defect undergoing open-heart surgery with ECC were studied.Blood samples were taken after induction of anesthesia(T0),30 minutes after the initiation ECC(T1),30 minutes after the termination ECC(T2) and 24 hours post-operatively(T3).PMN apoptosis and the expression of PMN Fas,Bcl-2 protein were detected by flow cytometry.RESULTS Compared with T0,the rate of PMN apoptosis reached to its lowest value at T2(P0.05).The percentage of PMN apoptosis correlated negatively with the duration of ECC(r=-0.648,P0.05).Fas on PMN membrane at T2 was significantly downregulated than T0.Fas levels correlated positively with PMN apoptosis rate(r=0.546,P0.05).PMN intracellular expression of Bcl-2 at T1,T2,T3 was significantly upregulated than T0(P0.05).Bcl-2 levels correlated negatively with PMN apoptosis rate(r=-0.569,P0.05).CONCLUSION The PMN apoptosis can be delayed by ECC.The inhibition of PMN apoptosis has relation with the down regulation expression of Fas and the upregulation expression of Bcl2." @default.
- W2368241926 created "2016-06-24" @default.
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- W2368241926 date "2008-01-01" @default.
- W2368241926 modified "2023-09-24" @default.
- W2368241926 title "Effects of Extracorporeal Circulation on Polymorphonuclear Neutrophil Apoptosis and Related Protein in Pediatric" @default.
- W2368241926 hasPublicationYear "2008" @default.
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