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- W2368251844 abstract "Objective To investigate the influence of Rosuvastatin on atherosclerosis plaques and inflammatory factors in rabbit model. Methods 36 male New Zealand rabbits were randomly divided into blank group,model group and Rosuvastatin group,with 12 rats in each group. The blank group was fed normally,the model group and Rosuvastatin group of rabbits were modeled by AS modeling,and the Rosuvastatin group of rabbits was fed with Rosuvastatin 1.5 mg/(kg·d). Lipid levels and inflammatory factor levels were detected before treatment,4 weeks,8 weeks and 12 weeks after treatment. The lumen area stenosis percentage(LAS) was compared by intravascular ultrasound imaging device at the end of treatment. Results The model group for 4 weeks,8 weeks and 12 week treatment were significantly higher than that of the same period of lipids in blank group(P 0.05 or P 0.01). Each index level of Rosuvastatin group was still increasing trend. Compared to the control group,there were significant differences after 4 weeks,8 weeks and 12 weeks of treatment(P 0.05 or P 0.01). However,compared with the model group,the levels of riglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C) were significantly lower than those of the same period in the model group level(P 0.05 or P 0.01). For the animals of the model group and the Rosuvastatin group,with the modeling process,monocyte chemoattractant factor(MCP-1),tumor necrosis factor alpha(TNFα) and interleukin-1(IL-1) level were significantly higher than those in the blank group after 4 weeks,8 weeks and 12 weeks of treatment(P 0.05 or P 0.01). Compared with the model group,the levels of inflammatory factors in rosuvastatin were significantly lower than those of the model group after 4 weeks,8 weeks and 12 weeks of treatment(P 0.05 or P 0.01). The animals lumen area stenosis percentage(LAS) of rosuvastatin group was(28.79±4.71)%,the LAS in the model group was(36.67±5.48)%,two groups were significantly different(P 0.05). Conclusion Rosuvastatin is better able to control the levels of lipid and inflammatory factors and reduce the plaque formation in the atherosclerosis model of rabbit." @default.
- W2368251844 created "2016-06-24" @default.
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- W2368251844 date "2013-01-01" @default.
- W2368251844 modified "2023-09-23" @default.
- W2368251844 title "Rosuvastatin on rabbit atherosclerotic plaques and levels of inflammatory cytokines" @default.
- W2368251844 hasPublicationYear "2013" @default.
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