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- W2368256204 abstract "Objective To explore the effects of triptolide on Glut-1 and Glut-3 expression in diabetic rat brain.Methods Forty-five rats were randomly divided into normal control group(n=13) and diabetic model group(n=32).In the model group,the rats were intraperitoneally injected with streptozotocin(STZ) 52 mg·kg-1 once daily for five consecutive days;in the normal control group,the rats were intraperitoneally injected with equal volume of citric acid 0.1 mol·L-1.Twenty-eight DM rat models were successfully established and divided into model control group(n=14) and triptolide(TP) group(n=14).Rats in the TP group were administered with triptolide suspension intragastrically at 1.8 g·kg-1 daily for 8 weeks,and those in the model control group were administered with equal volume of water.Results In normal control group,expression levels of Glut-1 and Glut-3 were higher in the hippocampus than in the cortex.In model control group,expression levels of Glut-1 and Glut-3 in the hippocampus and cortex were not changed significantly(P0.05).In TP group,Glut-1 expression in the cortex and hippocampus was(1.31±0.34)% and(1.03±0.25)%,significantly decreased(P0.01).Glut-3 in hippocampus was increased significantly(P0.01).Conclusion Triptolide can significantly lower the Glut-1 content in the diabetic rat brain." @default.
- W2368256204 created "2016-06-24" @default.
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- W2368256204 date "2013-01-01" @default.
- W2368256204 modified "2023-09-26" @default.
- W2368256204 title "Effects of Triptolide on Glucose Transporter Expression in Diabetic Rat Brain" @default.
- W2368256204 hasPublicationYear "2013" @default.
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