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- W2368270488 abstract "OBJECTIVE:To study the mechanism of hepatic lesion caused by antituberculosis drugs and prophylactic effect of reduced glutathione. METHODS: 116 patients were randomly divided into two groups, treatment group (61 cases) was given reduced glutathione and control group (55 cases) was given glucurolactone. RESULTS:The incidence of hepatic lesion in control group was 24 45%, but in treatment group was only 1 63%. There was a significant difference between these two groups( P 0 001). The serum level of lipid peroxides (LPO) in patients with hepatic lesion was significantly higher but the level of super oxide dismutase (SOD) activity was low. There was a great difference compared with that before treatment and in the patients with normal liver function( P 0 05).CONCLUSION:Hepatic lesion caused by antituberculosis drugs was related with peroxide of lipid, which can consume anti-oxides of the body. The use of reduced glutathione could obviously lower the occurrence of hepatic lesion caused by antituberculosis drugs." @default.
- W2368270488 created "2016-06-24" @default.
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- W2368270488 date "2004-01-01" @default.
- W2368270488 modified "2023-09-25" @default.
- W2368270488 title "The Mechanism of Hepatic Lesion Caused by Antituberculosis Drugs and Prophylactic Effect of Reduced Glutathione" @default.
- W2368270488 hasPublicationYear "2004" @default.
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