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- W2368276052 abstract "The aim of this study was to determine the sensitizing potency of morpholine (M), 4, 4'-dithiodimorpholine(DTDM), morpholinylmercaptobenzothiazole(MMBT) and 2-meroaptobenzothiazole (MBT) in guinea pigs. 5% and 10% DTDM, MMBT and MBT produced irritation reactions. M up to 10% failed to irritate. For all of the compounds studied, 5% in petrolatum was used as the induction concentration; 2%, 0.5% and 0.1% in petrolatum were used as challenge concentrations. All of the guinea pigs treated with DTDM and MMBT were sensitized; 70% of the animals were sensitized to MBT, none of the animals treated with M were sensitized. When the animals were subsequently retested for cross-sensitization, the following observation were made: 60% of the DTDM-sensitized animals reacted to challenge with MMBT, 30% of the animals sensitized to DTDM reacted to challenge with MBT, and 20% to challenge with M; 30% of the MBT-sensitized animals reacted to MMBT. The rank order of sensitization potential in guinea pigs as observed from this study is DTDM, MMBT and MBT. It appears that the disulfide bond, sulfur linkage and the sulfhy-aryl group may each play a role in the sensitizing capacity of these compounds." @default.
- W2368276052 created "2016-06-24" @default.
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- W2368276052 date "1986-01-01" @default.
- W2368276052 modified "2023-09-27" @default.
- W2368276052 title "COMPARISON STUDIES OF THE SENSITIZING POTENCY OF MORPHOLINE, 2-MERCAPTOBENZOTHIAZOLE AND TWO OF THEIR DERIVATIVES IN GUINEA PIGS" @default.
- W2368276052 hasPublicationYear "1986" @default.
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