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- W2368276883 abstract "Objective To explore the protective effect of MK-801 on nigrostriatal projection system in 6-hydroxydopamine(6-OHDA)-induced Parkinson disease(PD)models. Methods Forty rats were randomized to control group,6-OHDAtreated group,0.1mg/kg MK-801 pretreated group and 0.2mg/kg MK-801 pretreated group.6-OHDA was used to create PD rat models.Applying immunohistochemical method and high performance liquid chromatography to detect the number of tyrosine hydroxylase(TH)-positive neurons in the substantia nigra(SN)and dopamine contents in the striatum of rats,respectively. Results The number of TH-positive neurons in the SN and dopamine contents in the striatum decreased significantly in 6-OHDAtreated rats compared with the controls(F=478.02,34.86;q=51.25,14.09;P0.05).Compared with 6-OHDA-treated group,the numbers of TH-positive neurons and striatal DA contents in low-dose-treated and high-dose-treated groups obviously increased(q= 4.27-14.96,P0.05). Conclusion MK-801 shows a notable protective effect on nigrostriatal path action in rat models of 6-OHDA-induced PD." @default.
- W2368276883 created "2016-06-24" @default.
- W2368276883 creator A5081752136 @default.
- W2368276883 date "2015-01-01" @default.
- W2368276883 modified "2023-09-28" @default.
- W2368276883 title "THE PROTECTIVE EFFECT OF MK-801ON NIGROSTRIATAL PROJECTION SYSTEM IN 6-OHDA-INDUCED PARKINSON DISEASE MODELS" @default.
- W2368276883 hasPublicationYear "2015" @default.
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