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- W2368277509 abstract "Objective To investigate the reserved function of pituitary growth hormone(GH) in patients after surgery for non-somatotrophinoma(NSP).Methods Insulin tolerance test(ITT) was done in 23 patients after six months of surgery for NSP.Serum levels of glucose and GH were measured 30 min before and 0,30,45,60,90 and 120 min after the test.The blood sample taken 30 min before ITT was also used to detect the levels of IGF-Ⅰand IGFBP-3.Results The average level of IGF-Ⅰwas(0.32±0.14) g/L,which was negatively correlated with the age(r=-0.555,P0.05),that of IGFBP-3 was(5.92±1.15) g/L,not correlated with the age(r=0.036,P0.05).The average peak value of GH was(3.92±4.71) μg/L,with the peak value over 5.0 μg/L in four patients,and that of the rest 19 was under 5.0 μg/L,of whom,15 patients had the GH peak value under 3.0 μg/L.In those with the GH peak value under 5.0 μg/L,eight had the IGF-Ⅰand IGFBP-3 in range of normal values.The peak value of GH was not correlated with the lowest level of glucose(r=-0.352,P0.05).Conclusion Most patients with NSP will develop deficiency or severe deficiency of GH after surgery,for those with hypofunction of anterior pituitary after surgery for pituitary tumor,the GH reserved function assessment is needed.Besides routine supply of glucocorticosteroid and thyroid hormone,for those with deficiency or severe deficiency of GH,a long-term of GH-substitution therapy should be highly considered." @default.
- W2368277509 created "2016-06-24" @default.
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- W2368277509 date "2011-01-01" @default.
- W2368277509 modified "2023-09-24" @default.
- W2368277509 title "OBSERVATION ON THE RESERVED FUNCTION OF PITUITARY GROWTH HORMONE IN PATIENTS AFTER SURGERY FOR NON-SOMATOTROPHINOMA" @default.
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