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- W2368289548 abstract "Objective To detect circulating autoantibodies to human MCHR1 in sera of patients with vitiligo and evaluate its significance in episode of vitiligo.Methods After constructing a eukaryotic expression vector pcDNA3.1/MCHR1 for expression of MCHR1, it was identified by restriction endonuclease digestion and nucleotide sequencing. Then the vector pcDNA3.1/MCHR1 was transfected into CHO cells by mixing with lipofectamine 2000 reagent and screened with G418 to obtain stable expression. The expression of MCHR1 was identified by ELISA,RT-PCR and Western-blot assay. Then the autoantibodies to MCHR1 and melanocyte surface antigens in sera of patients with vitiligo and normal individuals were measured by using a live cell enzyme-linked immunoabsorbent assay. Results Anti-MCHR1 IgG antibodies were present in 17.1% of patients with vitiligo, contrastively anti-melanocyte IgG antibodies were 41.4%. All sera with anti-MCHR1 antibodies were positive to anti-melanocyte. The sera of normal individuals are all negative to anti-MCHR1 and anti-melanocyte.Conclusion There are anti-MCHR1 antibodies in sera of some patients with vitiligo. MCHR1 is one of vitiligo related antigen and it is located on melanocyte membrane." @default.
- W2368289548 created "2016-06-24" @default.
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- W2368289548 date "2005-01-01" @default.
- W2368289548 modified "2023-09-23" @default.
- W2368289548 title "Detection and Analysis of Autoantibodies of Human Melanin-Concentrating Hormone Receptor 1 in Sera of Patients with Vitiligo" @default.
- W2368289548 hasPublicationYear "2005" @default.
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