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- W2368303314 abstract "Microcin B17(MccB17) is a ribosomally synthesized peptide antibiotic,which inhibits its cellular target,DNA gyrase.Since its unique heterocycle-containing structure is so often found to be antitumour,antiviral or antibiotic in nature,MccB17 may prove to be a novel lead structure for the further general development of antimicrobial agents.The thiazole and oxazole ring-forming mechanisms found in MccB17 producing bacteria could prove to be a novel way of introducing new mimetic structure into peptides for use in the pharmaceutical industry.Results show MccB17 producing strain E.coli ZB43 accumulated more MccB17 in medium M63 than in medium LB.In shake flask,oxygen limitation improved the yield of MccB17.Glucose was repressive at the concentration over than 1g/L.The concentrations of fermentation medium,with glucose as carbon source,was optimized by uniform design U_(11)(11~(10)).The obtained optimal medium ingredients are:glucose 1g/L,KH_2PO_4 3g/L,K_2HPO_4 7g/L,(NH_4)_2SO_4 1g/L,MgSO_4·7H_2O 1.8mmol/L,thiamine 1.8μg/ml.Moreover,results show that succinate is an excellent carbon source for production of MccB17,which released the repression of glucose.When glucose was replace by succinate(10g/L) as sole carbon source in the optimal fermentation medium,at 37℃,the production yield of MccB17 reached 559.6μg/ml after fermentation for 24h." @default.
- W2368303314 created "2016-06-24" @default.
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- W2368303314 date "2005-01-01" @default.
- W2368303314 modified "2023-09-25" @default.
- W2368303314 title "Study on the Fermentation of Microcin B17 by E.coli ZB43" @default.
- W2368303314 hasPublicationYear "2005" @default.
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