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- W2368308098 abstract "Objective To further study the dynamic expressions of CD14 and scavenger receptor(SR)on the macrophages of the liver and the lung and their organic differences in mice. Methods Experimental mice were randomly divided into three groups including control group (4 mice), trauma group (Group TM, 40 mice) and traumatic endotoxin challenge group (Group TM+ET, 40 mice). The model mice with both femoral fracture and endotoxemia were used. The expressions of the CD14 and the SR on the macrophages of the liver and the lung were detected at the post traumatic 2nd, 4th, 6th, 9th and 13th hour in immunocytochemistry. Results After trauma, the expressions of the CD14 and the SR on the macrophages of the liver showed the tendency of up and down regulation respectively 9 hours after trauma ( P 0.05), while that of the lung showed the tendency of up and down regulation respectively 6 hours after trauma ( P 0.05). Furthermore, the post traumatic endotoxin challenge induces up regulation of the CD14 and down regulation of the SR significantly 2 hours after trauma ( P 0.05 and 0.01). Correlation analysis indicated that the CD14 and the SR had significantly negative relationship in both the liver and the lung ( r =-0.823,-0.797, P 0.01); meanwhile, there exist some differences between the liver and the lung on kinetics of the CD14 and the SR ( P 0.05 and 0.01). Conclusions The dynamic expressions of the CD14 and the SR on macrophages of the liver and the lung is characterized by two side modulation after trauma and endotoxin challenge, which may be a symbol of inflammatory transformation from self control to out of control. The expression differences of the CD14 and the SR in the liver and the lung may be correlated with the sequential organic injury after severe trauma and endotoxin challenge." @default.
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- W2368308098 date "2002-01-01" @default.
- W2368308098 modified "2023-09-24" @default.
- W2368308098 title "Expressions of CD14 and scavenger receptor on macrophages of liver and lung after severe trauma and endotoxin challenge in mice" @default.
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