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- W2368322133 abstract "OBJECTIVE:To investigate the preparation technique and optimal formulation of ketoconazole calcium alginate gel beads.METHODS:Ketoconazole calcium alginate gel beads were prepared by droplet method.The orthogonal experiment was carried out with encapsulation efficiency(EE)and drug loading(LD)as indexes to optimize the optimal formulation of the calcium alginate gel beads.The encapsulation efficiency and drug loading amount for the optimized formulation were determined,and the optimized formulation was compared with crude drug in respect of the in vitro drug release behavior.RESULTS:The result showed that the optimal formulation was as follows:2.0% Na-alginate and 0.3mol· L-1 CaCl2 with the ratio of Na-alginate:ketoconazole at 2∶ 1.The average EE and LD were(90.53± 2.32)% and(31.51± 2.08)%,respectively,and the slow-release was better as compared with that of the crude drug.CONCLUSION:The preparation procedure is simple,feasible,stable and reproducible." @default.
- W2368322133 created "2016-06-24" @default.
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- W2368322133 date "2007-01-01" @default.
- W2368322133 modified "2023-09-25" @default.
- W2368322133 title "Preparation Technology of Ketoconazole Calcium Alginate Gel Beads" @default.
- W2368322133 hasPublicationYear "2007" @default.
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