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- W2368327928 abstract "To investigate the adjunctive therapeutic efficacy of vitamin A(VA) on chickens artificially induced by Mycoplasma gallisepticum(MG) through observing the pathological change of lung tissue and the expression of pulmonary surfactant associated protein A.On the base of using the tylosin for conventional therepy,the chickens which had been infected by MG type strains were treated with different dose VA for adjunctive therapy,The adjunctive therapeutic efficacy of VA was evaluated through pathological change of lung tissue with hematoxylin and eosin for histological examination and the expression of SP-A by immunohistochemistry in order to explore the possible mechanism of pharmacodynamic action of VA.Compared with the healthy group,the model group in the degree of lung tissue injury was severe,the general tendency of the intensity and the number of SP-A positive cells was decreased significantly(P0.05);after treatment with tylosin and VA,the degree of lung tissue injury was relieved in different degree,especially in the VA middle dose group and high dose group(P0.01).The general tendency of the intensity and the number of SP-A positive cells increased significantly(P0.01),especially in the VA middle dose group and low group group(P0.01).VA could be helpful to adjunctive therapy for the chronic respiratory disease by protecting the structure and function of epithelial cell in the lung tissue,increaseing the expression of protein A,accelerating lung tissue repair,and the rational therapeutical dose was 1 200 IU/kg." @default.
- W2368327928 created "2016-06-24" @default.
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- W2368327928 date "2013-01-01" @default.
- W2368327928 modified "2023-09-24" @default.
- W2368327928 title "Mechanism of pharmacodynamic action in using vitamin A to adjunctive therap the chronic respiratory disease" @default.
- W2368327928 hasPublicationYear "2013" @default.
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