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- W2368337488 abstract "Objective We examined the effect of chronic cerebral hypoperfusion on the the expression of Poly(ADP-ribose) Polymerase(PARP) in rat hippocampus and studied the role of sodium ferulate in oxidative stress during chronic cerebral hypoperfusion. Methods Bilateral common carotid arteries were permanently double ligated in 10 Wistar rats. 10 rats were administered sodium ferulate after chronic cerebral ischemic immediately. Other 8 rats were sham-operated group. The contents of malondialdehyde (MDA)in the hippocampus were detected. The levels of PARP protein was measured by Western blot. Results The content of MDA after chronic cerebral hypoperfusion increased significantly. The levels of PARP were higher than that of the sham-operated group. In sodium ferulate-treated rats,the level of MDA and PARP were lower than that of the group of 2-VO. Conclusion Chronic cerebral hypoperfusion can induced oxidative stress and increased reactive oxygen hydroxyl ions,which can produce lipidperoxide,induce DNA damage,resulte activation of poly(ADP-ribose) polymerase. Sodium ferulate can protect brain against oxidative damage after chronic cerebral ischemia." @default.
- W2368337488 created "2016-06-24" @default.
- W2368337488 creator A5058524052 @default.
- W2368337488 date "2005-01-01" @default.
- W2368337488 modified "2023-09-27" @default.
- W2368337488 title "Chronic cerebral hypoperfusion induces poly(ADP-ribose) polymerase and MDA upregulation in rat hippocampus and the protection of sodium ferulate against oxidative stress" @default.
- W2368337488 hasPublicationYear "2005" @default.
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