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- W2368339352 abstract "AIM Rosiglitazone maleate intragastric floating sustained release tablet was developed based on the hydrodynamically balanced drug delivery system, which could prolong the residence time of drug in the stomach and improve the bioavailability. METHODS The amount of expicents, preparing methods and drug release %in vitro% of the formulation were determined by floating and drug releasing conditions as screening index with orthogonal design test and single factor test methods. Rosiglitazone maleate sustained release tablet and traditional tablet (Avandia) were radio labeled with 99 mTc, and their behavior in stomach was detected by r ray camera techniques. RESULTS The optimum formulation kept sustained floating and release in media for 12 h. The floating tablet was remained in the stomach for more than 3 h without disintegrating. CONCLUSION Drug release of sustained release tablet in media was in agreement with Higuchi equation, and the releasing mechanism was irregular diffusion. The gastric residence time of the subjects after oral administration floating tablet was obviously longer than that after oral administration conventional tablet." @default.
- W2368339352 created "2016-06-24" @default.
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- W2368339352 date "2002-01-01" @default.
- W2368339352 modified "2023-09-24" @default.
- W2368339352 title "Studies on Rosiglitazone Maleate Intragastric Floating Sustained Release Tablet" @default.
- W2368339352 hasPublicationYear "2002" @default.
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