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- W2368339747 abstract "Objective To study CD137 L expression in non-small cell lung cancer,its effect on cell proliferation,migration and invasion and explore the molecular mechanisms of non-small cell lung cancer invasion and metastasis. Methods Lentiviral vectors of CD137 L overexpression,CD137L-RNA interference and A549 control were constructed and transfected into A549 cell. CD137 L protein expression in three groups were detected by Western blot; cell proliferation assay were conducted by MTT; cancer cells proliferation,invasiveness were measured by Matrigel transwell chamber invasion assay; IL-6 and IL-8 levels in cell supernatants were detected by ELISA method. Results Western blot results showed that: compared with A549 cell,CD137 L protein expression in A549-TC-1( +) cell increased significantly,A549-TC-1(-) cell decreased significantly,the differences were all statistically significant( P 0. 05),and there was little change in transfected A549-control cell,which indicating that three kinds of viral vectors can be used for subsequent experiments.. MTT and matrigel transwell chamber invasion assay results showed that: compared with A549-control cell,A549-TC-1( +) cell proliferation migration and invasion capacity were enhanced,and A549-TC-1( +) cell were weakened,the differences were all statistically significant( P 0. 05). ELISA results showed that cell serum IL-6,IL-8 levels in A549-TC-1( +) cell were all significantly higher than A549-TC-1(-)cell and normal A549 cell a groups. Conclusion CD137 L can regulate non-small cancer cell proliferation and invasion positivily,the mechanism may related to increasing IL-6,IL-8 secretion and thereby enhancing tumor growth,proliferation and invasion." @default.
- W2368339747 created "2016-06-24" @default.
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- W2368339747 date "2014-01-01" @default.
- W2368339747 modified "2023-09-23" @default.
- W2368339747 title "The role and mechanism of CD137L in non-small cell lung cancer proliferation,migration and invasion" @default.
- W2368339747 hasPublicationYear "2014" @default.
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