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- W2368341210 abstract "Objective To approach the association between human leucocyte antigen(HLA)-DQB1 allele gene polymorphism and multiple sclerosis(MS) in Han population from southern area of China.Methods The HLA-DQB1 genotypes of the 42 Han patients with MS(MS group) and 48 healthy controls(healthy control group) all of them from southern area of china were determined by sequencing-based typing(SBT) method.The frequencies of the DQB1 alleles were compared between the two groups.Results A total of 15 DQB1 allele genes were identified.The frequency of the DQB1*0502 allele gene in the MS group(35.7%) was significantly higher than that in the healthy control group(8.9%)(P=0.0018,Pc=0.027,OR=4.29).The frequency of the DQB1*0303 allele gene in the MS group(19.0%) was lower than that in the healthy control group(39.6%)(P=0.04,OR=0.48),but the difference was no statistical significance since corrected.In addition,the freguencies of HLA-DQB1*0601 and DQB1*0602 allele genes were no significantly difference between the MS group and health control group.Conclusion MS in Han population from southern area of China is associated with HLA-DQB1*0502 allele gene,but not with the DQB1*0301 and DQB1*0602 allele genes." @default.
- W2368341210 created "2016-06-24" @default.
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- W2368341210 date "2011-01-01" @default.
- W2368341210 modified "2023-09-24" @default.
- W2368341210 title "Study of association between human leucocyte antigen-DQB1 allele gene polymorphism and multiple sclerosis in Han population from southern area of China" @default.
- W2368341210 hasPublicationYear "2011" @default.
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