Matches in SemOpenAlex for { <https://semopenalex.org/work/W2368346312> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2368346312 abstract "Objective To investigate the relationship between cytotoxicity and oxidative stress induced by different kinds of arsenicals in human embryo skin fibroblasts cells(CCC-ESF-1).Methods Cultured CCC-ESF-1 was exposed to Arsenic Trioxide(As2O3,iAs Ⅲ),Hydrogen sodium arsenate(Na2HAsO4·7H2O,iAsⅤ) or sodium dimethylarsonate(DMAV) of 0 to 400 μmol/L for 48h,respectively.MTT assay were used to evaluate the cell viability and the malondialdehyde(MDA) content and the activity of the superoxide dismutase(SOD) in CCC-ESF-1 were detected respectively.Results iAsⅢ(≥12.5 μmol/L),iAsⅤ(≥12.5μmol/L)and DMAV(≥50.0μmol/L)could all decrease the cell viability in a dose-dependent manner in a certain dose range(P0.01,P0.05).The IC50 values for iAsⅢ,iAsⅤ and DMAV were determined to be approximately 16.52μmol/L、55.47μmol/L and 500.0μmol/L,respectively.The 25.0,50.0 μmol/L As2O3(iAsⅢ)and 200.0μmol/L Na2HAsO4·7H2O(iAsⅤ)induced the significant increase of the MDA contents compared to those in the control group(P0.05).The SOD activity in1.0,50.0μmol/L Na2HAsO4·7H2O group was significantly higher than that in the control group(P0.05),while the SOD activity induced by ≥12.5μmol/L As2O3,200.0 μmol/L Na2HAsO4·7H2O and ≥12.5μmol/L C2H6AsO2Na·3H2O were significantly decreased(P0.01,P0.05),there were the dose-effect relation of inverted U curves.Conclusion The different arsenicals on CCC-ESF-1 cells have different cell toxicity,which As2O3(iAs Ⅲ) is highly toxic in CCC-ESF-1.The one of mechanisms probably relates to different levels of oxidative stress induced by arsenicals of different concentrations." @default.
- W2368346312 created "2016-06-24" @default.
- W2368346312 creator A5078229397 @default.
- W2368346312 date "2011-01-01" @default.
- W2368346312 modified "2023-09-24" @default.
- W2368346312 title "Cytotoxicity study of human embryo skin fibroblasts cells by different kinds of arsenicals" @default.
- W2368346312 hasPublicationYear "2011" @default.
- W2368346312 type Work @default.
- W2368346312 sameAs 2368346312 @default.
- W2368346312 citedByCount "0" @default.
- W2368346312 crossrefType "journal-article" @default.
- W2368346312 hasAuthorship W2368346312A5078229397 @default.
- W2368346312 hasConcept C109316439 @default.
- W2368346312 hasConcept C124815738 @default.
- W2368346312 hasConcept C13965031 @default.
- W2368346312 hasConcept C153911025 @default.
- W2368346312 hasConcept C178790620 @default.
- W2368346312 hasConcept C185592680 @default.
- W2368346312 hasConcept C196843134 @default.
- W2368346312 hasConcept C202751555 @default.
- W2368346312 hasConcept C2775838275 @default.
- W2368346312 hasConcept C2776151105 @default.
- W2368346312 hasConcept C2776630066 @default.
- W2368346312 hasConcept C2777752497 @default.
- W2368346312 hasConcept C2777764464 @default.
- W2368346312 hasConcept C2778401633 @default.
- W2368346312 hasConcept C2779495234 @default.
- W2368346312 hasConcept C2780386689 @default.
- W2368346312 hasConcept C2780783641 @default.
- W2368346312 hasConcept C502230775 @default.
- W2368346312 hasConcept C53227056 @default.
- W2368346312 hasConcept C54355233 @default.
- W2368346312 hasConcept C55493867 @default.
- W2368346312 hasConcept C81885089 @default.
- W2368346312 hasConcept C86803240 @default.
- W2368346312 hasConcept C95444343 @default.
- W2368346312 hasConceptScore W2368346312C109316439 @default.
- W2368346312 hasConceptScore W2368346312C124815738 @default.
- W2368346312 hasConceptScore W2368346312C13965031 @default.
- W2368346312 hasConceptScore W2368346312C153911025 @default.
- W2368346312 hasConceptScore W2368346312C178790620 @default.
- W2368346312 hasConceptScore W2368346312C185592680 @default.
- W2368346312 hasConceptScore W2368346312C196843134 @default.
- W2368346312 hasConceptScore W2368346312C202751555 @default.
- W2368346312 hasConceptScore W2368346312C2775838275 @default.
- W2368346312 hasConceptScore W2368346312C2776151105 @default.
- W2368346312 hasConceptScore W2368346312C2776630066 @default.
- W2368346312 hasConceptScore W2368346312C2777752497 @default.
- W2368346312 hasConceptScore W2368346312C2777764464 @default.
- W2368346312 hasConceptScore W2368346312C2778401633 @default.
- W2368346312 hasConceptScore W2368346312C2779495234 @default.
- W2368346312 hasConceptScore W2368346312C2780386689 @default.
- W2368346312 hasConceptScore W2368346312C2780783641 @default.
- W2368346312 hasConceptScore W2368346312C502230775 @default.
- W2368346312 hasConceptScore W2368346312C53227056 @default.
- W2368346312 hasConceptScore W2368346312C54355233 @default.
- W2368346312 hasConceptScore W2368346312C55493867 @default.
- W2368346312 hasConceptScore W2368346312C81885089 @default.
- W2368346312 hasConceptScore W2368346312C86803240 @default.
- W2368346312 hasConceptScore W2368346312C95444343 @default.
- W2368346312 hasLocation W23683463121 @default.
- W2368346312 hasOpenAccess W2368346312 @default.
- W2368346312 hasPrimaryLocation W23683463121 @default.
- W2368346312 hasRelatedWork W2226231373 @default.
- W2368346312 hasRelatedWork W2353746737 @default.
- W2368346312 hasRelatedWork W2381994253 @default.
- W2368346312 hasRelatedWork W2404878622 @default.
- W2368346312 hasRelatedWork W2414381049 @default.
- W2368346312 hasRelatedWork W2414966981 @default.
- W2368346312 hasRelatedWork W2416350709 @default.
- W2368346312 hasRelatedWork W2460970713 @default.
- W2368346312 hasRelatedWork W2472420548 @default.
- W2368346312 hasRelatedWork W2482968546 @default.
- W2368346312 hasRelatedWork W2968648090 @default.
- W2368346312 hasRelatedWork W2992186118 @default.
- W2368346312 hasRelatedWork W3029119386 @default.
- W2368346312 hasRelatedWork W3029546288 @default.
- W2368346312 hasRelatedWork W3030031521 @default.
- W2368346312 hasRelatedWork W3032227113 @default.
- W2368346312 hasRelatedWork W3032311237 @default.
- W2368346312 hasRelatedWork W3032749874 @default.
- W2368346312 hasRelatedWork W3140804954 @default.
- W2368346312 hasRelatedWork W3145997591 @default.
- W2368346312 isParatext "false" @default.
- W2368346312 isRetracted "false" @default.
- W2368346312 magId "2368346312" @default.
- W2368346312 workType "article" @default.