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- W2368348257 abstract "Objective To investigate the protective effect of salvianolate on the iron overload-derived oxidative stress injury of mononuclear cells of umbilical cord blood( UC-MNCs). Methods The UC-MNCs were divided into the control group,FAC group,low-dose salvianolate group,medium-dose salvianolate group,and high-dose salvianolate group. The control group received normal culture. The iron overload cell models in the FAC and salvianolate groups were established by adding 400 μmol / L FAC into the culture medium for 24 h on the second day. Then the low-dose,medium-dose and highdose salvianolate groups were received 18,50 and 160 μg / m L salvianolate for 24 h,respectively on the third day. Then the levels of reactive oxygen species( ROS),apoptosis rate and LIP level were detected by flow cytometry,respectively. Results The ROS level of the FAC group was higher than that of the control,the low-dose,medium-dose and high-dose salvianolate groups( all P 0. 05). The apoptosis rate in the FAC group was higher than that of the control group and highdose salvianolate group( P 0. 05). The counts of colony-forming unit-erythroid( CFU-E),granulocyte-macrophage colony-forming units( CFU-GM),erythropoietic burst-forming units( BFU-E) and mixed progenitor cell colony-forming units( CFU-mix) in the FAC group were significantly lower than those of the control group and high-dose salvianolate group( P 0. 05). Conclusions Salvianolate can reduce the oxidative stress caused by apoptosis and inhibition of proliferation and differentiation of hematopoietic cells." @default.
- W2368348257 created "2016-06-24" @default.
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- W2368348257 date "2015-01-01" @default.
- W2368348257 modified "2023-09-23" @default.
- W2368348257 title "Inhibitory effect of salvianolate on iron overload-derived oxidative stress injury of hematopoietic cells of umbilical cord blood" @default.
- W2368348257 hasPublicationYear "2015" @default.
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