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- W2368364240 abstract "AIM: To evaluate and compare losartan and amlodipine on the hypotensive effect and reverse reduction of left ventricular hypertrophy. METHODS: One hundred and twenty hypertensive patients with left ventricular hypertrophy were randomly divided into two groups: losartan group of 60 patients was treated with losartan 25-50 mg, po , qm for 24 wk and amlodipine group of 60 patients was treated with amlodipine 5-10 mg , po , qm for 24 wk. Twenty-four hours ambulatory blood pressure monitoring and color Doppler echocardiography were performed before and after treatment. RESULTS: After treatment of 24 wk, in losartan group SBP, DBP were reduced (3.4±1.5) kPa and (2.7±0.7)kPa; in amlodipine group SBP,DBP were reduced (3.2±1.5) kPa and (2.0±0.9) kPa, there were significant difference by t test ( P 0.01), SBP had no obvious differences ( P 0.05) and DBP were significantly decreased ( P 0.01) in the two groups. After 24 wk treatment with both drugs interventricular septum thickness, left ventricular posterior wall thickness, left ventricular mass and index of left ventricular mass were improved significantly ( P 0.01). CONCLUSION: Losartan and amlodipine can significantly reduce the blood pressure level and have reverse reduction of left ventricular hypertrophy in hypertensive patients with left ventricular hypertrophy. The therapeutic effect of losartan is similar to that of amlodipine." @default.
- W2368364240 created "2016-06-24" @default.
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- W2368364240 date "2001-01-01" @default.
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- W2368364240 title "Comparison of losartan and amlodipine for anti hypertension and amelioration of left ventricular hypertrophy" @default.
- W2368364240 hasPublicationYear "2001" @default.
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