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- W2368366513 abstract "Background: Therapy of eradicating Helicobacter pylori (H. pylori) is much more commonly applied clinically. However,the emergence of resistance strains of H. pylori lowers the eradication rate,especially resistant to clarithromycin,one of the most effective antibiotics. Aims:% To explore the genotype distribution of clarithromycin resistant H. pylori,which may provide a basis for rapid detection of drug resistance. Methods: Thirteen primary and 22 acquired clarithromycin resistant H. pylori strains from Sep. 2002 to Feb. 2003 were selected by agar dilution method. Genomic DNA was extracted. Seven different point mutations (A2115G,G2141A,A2142G,A2142C,A2143G,A2143C,and A2142T) in the region of 23S rRNA gene of clarithromycin resistant H. pylori strains were detected by polymerase chain reaction (PCR)-reverse dot hybridization. Results: A2143G mutation was detected in 97.1% (34/35) of H. pylori strains resistant to clarithromycin,including 13 primary and 21 acquired strains; only 1 (2.9%) acquired clarithromycin resistant H. pylori strain showed A2142G mutation. Conclusions: A2143G mutation in 23S rRNA gene is the predominant type of H. pylori resistant to clarithromycin in China,which is different from the Western countries with near mutation rates of A2142G and A2143G." @default.
- W2368366513 created "2016-06-24" @default.
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- W2368366513 date "2008-01-01" @default.
- W2368366513 modified "2023-09-26" @default.
- W2368366513 title "Genotype Distribution of Clarithromycin Resistant Helicobacter pylori Strains" @default.
- W2368366513 hasPublicationYear "2008" @default.
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