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- W2368373033 abstract "Objective To investigate the role of mitochondrial biogenesiss in the therapeutic effect of cannabinoid receptor 1(CB1R)highly selective agonist ACEA after cerebral ischemia reperfusion.Methods Adult male Sprague-Dawley(SD)rats were randomly divided into 3groups(n=8):Sham group(group S),Control group(group C),ACEA 1mg/kg group(group A).Cerebral ischemic injury was induced by middle cerebral artery occlusion(MCAO).ACEA 1mg/kg(group A)and vehicle(group C)were injected intraperitoneally 1hafter cerebral ischemia and reperfusion.The expression of Nrf-1and Tfam were analyzed by Western blot at 4hafter reperfusion.The mitochondrial volume and numbers was detected by electron microscopic(EM)at 4hafter reperfusion.Results At4 hafter reperfusion,the expression of Nrf-1and Tfam was obviously improved in group A compared with group C(P0.05).The volume of mitochondria was significantly improved in group A compared with group C(P0.05).Conclusion CB1 Rhighly selective agonist ACEA can induce mitochondrial biogenesis at the beginning of cerebral ischemia reperfusion.This may be involved in the neuroprotective effect induced by ACEA." @default.
- W2368373033 created "2016-06-24" @default.
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- W2368373033 date "2015-01-01" @default.
- W2368373033 modified "2023-09-23" @default.
- W2368373033 title "The effect of CB1R highly selective agonist ACEA on mitochondrial biogenesis after cerebral ischemia reperfusion" @default.
- W2368373033 hasPublicationYear "2015" @default.
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