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- W2368384025 abstract "Background and purpose:TrkB,a neurotrophic tyrosine kinase receptor,serves as a potent and specific suppressor of anoikis of non-malignant epithelial cells,and induces high invasion capacity in these cells.TrkB over-expression has been associated with chemotherapy resistance and poor survival in neuroblastoma and some other highly aggressive cancers.However,the relationship of the expression of TrkB to anoikis resistance in ovarian cancer cells has rarely been reported in literature.This study investigated the expression and significance of anoikis- suppressor TrkB in OVCAR-3 ovarian cancer cells.Methods:The expression of TrkB and its ligand BDNF was evaluated in OVCAR-3 ovarian cancer cells under different culture conditions by RT-PCR and Western blot.Results: TrkB mRNA was overexpressed in multicellular spheroids(cell-spheroids,anchorage-independent culture,AIC)as compared to that in OVCAR-3 cells(adhesive-cells,adhesive culture,AC),(35.3±0.7)% versus(23.5±0.5)%;but BDNF mRNA expression was the opposite to the above situation,(41.4±0.6)% versus(32.24±0.7)%(P0.001).Full- length TrkB(glycosylated receptor,145 000)was overexpressed in OVCAR-3 cell-spheroids compared with OVCAR-3 adhesive-cells(P0.001),and full-length TrkB protein precursor(non-glycosylated receptor)was highly overexpressed in OVCAR-3 ovarian cancer cells under different culture conditions without statistical difference by Western blotting. Conclusions:There was a TrkB and BDNF autocrine-loop in OVCAR-3 ovarian cancer cells.TrkB may acts as an anoikis-suppressor in human ovarian cancer." @default.
- W2368384025 created "2016-06-24" @default.
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- W2368384025 date "2008-01-01" @default.
- W2368384025 modified "2023-09-23" @default.
- W2368384025 title "Expression of tyrosine kinase receptor B in OVCAR-3 ovarian cancer cells and its significance" @default.
- W2368384025 hasPublicationYear "2008" @default.
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