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- W2368401434 abstract "Objective To investigate the effects of hemeoxygenase-1(HO-1)on caspase-12 in hippocampus neurons with oxygen glucose deprivation(OGD).Methods Hippocampus neurons of rats were cultured for 7 days before experiment.For oxygen glucose deprivation(OGD)experiments,cultures were washed three times in a glucose-free balanced salt solution(BSS).They were then placed in deoxygenated glucose-free medium and sealed under 95% N2 5% CO2 in an anaerobic chamber equilibrated to 37 ℃ and 100% humidity for 45 min.OGD was terminated by replacement of stored medium and by returning the cultures to a standard incubator maintained at 37 ℃ in 95% air-5% CO2.Experimental group cells were respectively carried out 10 μmol/L Heme precondition(group C+H),OGD(group D),10 μmol/L-Heme precondition+ OGD(group D+H),Control cells were cultured normally(group C).Compound remained present throughout the duration of the experiment until analysis 24 h later.Neuron viability and apoptosis were measured.The expression of HO-1,Caspase-12,Caspase3 protein were detected,Results The expression of HO-1 protein increased(vs group C,P0.01),Caspase 12,Caspase3,neuron viability and apoptosis changed without statistical difference(vs group C,P0.05) in group C+H.HO-1 protein decreased(vs group C,P0.01),Caspase-12,Caspase-3 increased(vs group C,P0.01),neuron viability decreased and apoptosis increased(vs group C,P0.01)in group D.HO-1 protein increased(vs group D,P0.01),Caspase-12,Caspase-3 decreased(vs group D,P0.01),neuron viability increased and apoptosis decreased(vs group D,P0.01)in group D+H.Conclusion HO-1 can inhibit expression of caspase-12 in hippocampus neurons with oxygen glucose deprivation and eventually inhibit neuron apoptosis." @default.
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- W2368401434 date "2009-01-01" @default.
- W2368401434 modified "2023-09-25" @default.
- W2368401434 title "Inhbiting Effects of Hemeoxygenase-1 on Expression of Caspase-12 in Hippocampus Neuron with Oxygen Glucose Deprivation" @default.
- W2368401434 hasPublicationYear "2009" @default.
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