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- W2368402012 abstract "Objective To elucidate the mechanism of immune protection for a donkey leukocyte attenuated vaccine(DLV)against Equine Infectious Anemia Virus(EIAV)by examining the relationship between immune protection and the levels of IL-12 mRNA transcription in peripheral blood mononuclear cells(PBMC)from immunized horses.Methods A real-time PCR method was established to detect the levels of IL-12 mRNA transcription in horse PBMC.Twelve horses were divided into four groups:vaccination group,healthy negative control group, positive control group with viral challenge and EIAV natural infection group.The levels and distribution of IL-12 mRNA transcription in PBMCs were analyzed.The body temperature of the inoculated horses was monitored on a daily basis.Horses inoculated with DLV vaccine were challenged 8 months post-inoculation,and the level of IL-12 mRNA transcription in PBMCs was evaluated pre-and post-challenge.Results The level of IL-12 mRNA transcription in vaccinated group was only slightly higher than in the healthy control and naturally infected groups.It became significantly higher after being challenged with virulent EIAV strain and four vaccinated horses were completely protected.In this challenged group,the level of IL-12 mRNA fluctuated as the disease progressed,and descended during the febrile episodes.Conclusion This study for the first time revealed that attenuated EIAV vaccine could induce high level transcription of IL-12 mRNA,which was correlated closely with immune protective response induced by DLV.This finding provided new information regarding to the mechanism of immune protection for DLV at the molecular level." @default.
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- W2368402012 date "2006-01-01" @default.
- W2368402012 modified "2023-09-23" @default.
- W2368402012 title "Induction of IL-12 transcription by PBMC of EIAV vaccinated horses" @default.
- W2368402012 hasPublicationYear "2006" @default.
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