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- W2368407825 abstract "Objective: To observe the efficacy and safety of combination of different dose of dexmedetomidine and intercostals never block in breast sectionn operation. Methods: By age number,using completely randomized grouping,patients were randomly divided into 4 groups: simple intercostal nerve block group(INB group) and low,medium and high dose of dexmedetomidine compound intercostal nerve block groups(D1,D2 and D3 group),D1,D2,D3 groups were treated by 0.7 μg·kg-1dexmedetomidine as loading and 0.25 μg·kg-1·h-1,0.5 μg·kg-1·h-1and 1 μg·kg-1·h-1as maintenance doses,respectively. To assess the effects,MAP,HR,SPO 2,RAMSAY,VAS circulation,respiration,sedation,analgesia and anesthesia overall indicators were monitored and recorded before intercostal nerve block(T0),after 30 min of anesthesia(T1),at the start of the skin incision(T2),when stretching deep tissues during surgery(T3) and one hour after surgery(T4). Results: MAP and HR in group D2,D3 were significantly lower than those in group INB and group D1 in time points T1,T2 and T3,but in group D3,bradycardia and hypotension happened more frequently(P0.05). In D2 and D3 groups,VAS at time points T2,T3 and T4 of were lower than those in group INB and D1; D1,D2 and D3 groups were better than INB group in RAMSAY scoring,but group D3 showed the phenomenon of excessive sedation(P0.05). Conclusion: The 0.5 μg·kg-1·h-1maintenance dose of dexmedetomidine compound intercostal nerve block can be applied to the breast section surgery sedation with more satisfied analgesia,smooth breathing and circulation and fewer side effects." @default.
- W2368407825 created "2016-06-24" @default.
- W2368407825 creator A5051680460 @default.
- W2368407825 date "2013-01-01" @default.
- W2368407825 modified "2023-09-23" @default.
- W2368407825 title "Dose Effect of Dexmedetomidine Combined with Intercostal Never Block in the Operation of Breast Section" @default.
- W2368407825 hasPublicationYear "2013" @default.
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