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- W2368407856 abstract "Objective To study the expressions in primary breast carcinomas,clinic significance of ERK and the relationship between it and bFGF protein as well.Methods The expression of ERK and bFGF protein was studied in 90 breast carcinoma samples,10 breast benign lesions samples as well as 15 adjacent normal tissues by SP inmmunohistochemical(IHC) analysis.Results The positive rates for ERK and bFGF expression were 81.1% and 62.2% respectively in breast cancer tissues,and there was obvious difference when compared with cancer adjacent normal tissues and breast benign lesion.There was no significant difference between the expression of ERK,tumor size,histologic type and histologic grade(P0.05).The expression of bFGF protein in breast cancer had nothing to do with tumor size,histologic type and histologic grade(P0.05).The protein expression of ERK and bFGF were correlated with each other(P0.05) closely.Conclusions The over-expression of ERK in breast cancer tissues was coupled with pathological grade,which indicated it may play an important role in carcinogenesis and progression of breast cancer,and it should be a target gene in therapy of breast cancer.ERK and bFGF may play synergetic roles in the process of carcinogenesis of breast carcinomas." @default.
- W2368407856 created "2016-06-24" @default.
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- W2368407856 date "2008-01-01" @default.
- W2368407856 modified "2023-09-28" @default.
- W2368407856 title "Expression and Significance of ERK and bFGF Protein in Primary Breast Cancer" @default.
- W2368407856 hasPublicationYear "2008" @default.
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