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- W2368412455 abstract "Objective To study the expression of Akt/PKB in hippocampus of cerebral ischemia-reperfusion rats after breviscapine was injected.Methods The ischemia-reperfusion model was induced with Zea-Longa′s way. Seventy-two SD rats were randomly divided into the sham group,ischemia-reperfusion group(I/R)and breviscap- ine group(Br)at different time points(3,12,24,48h)after reperfusion on average.The expression of Akt in hippocampus of all groups was examined by immunochemistry and Western blotting methods.Results Compared with the sham group,the positive expression of Akt in hippocampus of the rats in I/R group was decreased signifi- cantly at the point of 3hafter reperfusion(P 0.05),to the peak at 24h;compared with the rats in I/R group at the same time point,the positive expression of Akt didn′t evidently increase at the point of 3hafter breviscap- ine was injected(P 0.05),and increased significantly in 12,24,48hgroups(P 0.05);and the same result was obtain by western blotting method.Conclusion Breviscapine could up-regulate the expression of Akt in hip- pocampus of cerebral ischemia-reperfusion rats." @default.
- W2368412455 created "2016-06-24" @default.
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- W2368412455 date "2013-01-01" @default.
- W2368412455 modified "2023-09-25" @default.
- W2368412455 title "The effect of breviscapine on the expression of Akt in hippocampus of cerebral ischemia-reperfusion rat" @default.
- W2368412455 hasPublicationYear "2013" @default.
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