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- W2368414164 abstract "Objective To explore the pharmacokinetics and possibility to pass through the blood brain barrier of the recombinant human erythropoietin(EPO) in neonate with hypoxic-ischemic encephalopathy(HIE) by measuring the erythropoietin concentration in blood and cerebrospinal fluid(CSF).Methods Moderate and severe HIE infants were randomized to pre-treatment group(n=10) and treatment group of 3 h(n=10),8 h(n=8) and 24 h(n=7)after a single subcutaneous EPO administration with a dose of 500 U/kg.The EPO concentration in blood and CSF were measured by imunoradioassay.Results The EPO concentration in blood reached peak at 3 h after treatment,which was 2.6 times higher than that in before treatment patients(P0.01).It decreased after that and still kept high level at 24 h after EPO administration even though no significant differentce.The EPO concentration in CSF had a similar tendency with that in blood and reached peak at 3 h post EPO injection,which was significantly higher than that in patients of before treatment(P0.05),but it recovered at 8 h.Regression analysis showed that EPO concentration in blood and CSF was positively correlated at 3 h after EPO administration(r=0.69 P0.05).But other groups had no correlations.Conclusions EPO can pass through the blood brain barrier in HIE infants.The EPO concentration in CSF is correlated with EPO concentration in blood." @default.
- W2368414164 created "2016-06-24" @default.
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- W2368414164 date "2007-01-01" @default.
- W2368414164 modified "2023-09-28" @default.
- W2368414164 title "Changes of Pharmacokinetics of Erythropoietin in Neonate with Hypoxic-Ischemic Encephalopathy" @default.
- W2368414164 hasPublicationYear "2007" @default.
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