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- W2368434023 abstract "Objective To investigate the hepatitis B virus (HBV) drug-resistant mutations against nucleos (t)ide analogues of the patients with chronic hepatitis B in Guilin region for designing more effective therapeutic strategies. Methods Serum HBV DNA was extracted and a nested PCR was employed for HBV reverse transcriptase gene amplification.Direct sequencing of PCR product was performed and the results were analyzed by Vector NTI Suite 8.0 and chromaslite201 tools.Then the viral genotype was identified after phylogenetic analysis by Mega4.0 software. Results Eighteen patients were detected to be drug-resistant mutations in 171 patients and the rtA181 substitution was found in 7 patients (38.9% of total drug-resistant mutations number). The multidrug-resistant strains of HBV were found in 12 patients (66.7% of total). The percentages of the genotype B and C of drug-resistant mutations were 10.4% and 10.8% respectively. There was no statistical difference between the two genotypes in the patients (P 0.05). Conclusions The combination of the drug-resistant mutations in the patients with chronic HBV infection in Guilin region was complicated and the multidrug-resistant strains of HBV were dominant. There were no significant differences between the ratios of the HBV genotypes of drug-resistant mutations in these patients." @default.
- W2368434023 created "2016-06-24" @default.
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- W2368434023 date "2012-01-01" @default.
- W2368434023 modified "2023-09-25" @default.
- W2368434023 title "Analysis of hepatitis B virus (HBV) drug-resistant mutations against nucleos(t)ide analogues of the patients with chronic HBV infection in Guilin region" @default.
- W2368434023 hasPublicationYear "2012" @default.
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