Matches in SemOpenAlex for { <https://semopenalex.org/work/W2368452469> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2368452469 endingPage "6" @default.
- W2368452469 startingPage "423" @default.
- W2368452469 abstract "To investigate the effect of exogenous TGF-β1 on improving periodontal tissues remodeling during orthodontic tooth movement in rats.Eighty male SD rats were randomly divided into 2 groups. Rats in the experimental group were injected respectively with rhTGF-β1 in dosages of 0.1 mL (5 ng/mL) in the buccal submucosal area of the molar every other day, while rats in the control group received equivalent volumes of PBS. Each group (n=40) was subdivided equally into 5 subgroups. An orthodontic appliance, consisting of a 5 mm nickel titanium closed coil spring, was ligated between the maxillary left incisor and first molar of each rat to deliver an initial force of 0.49N. Eight rats in each subgroup were sacrificed at one of the five time points (1, 4, 7, 10 and 14 days) after appliance placement. The distance of the tooth movement was measured by using stereomicroscope. Tissue sections around the first maxillary left molar were stained with tartrate-resistant acid phosphatase (TRAP) histochemistry to analyze the changes of the amount and distribution of osteoclasts on the compression side of tooth. Statistical analysis was performed using SPSS 17.0 software package.Molars treated with rhTGF-β1 moved mesially more rapidly than the control group. The distance of tooth movement of the experimental group showed a significant increase compared with the control group at day 7 (P<0.05) and significant increase compared with the control group at day 10 and 14 (P<0.01). The number of TRAP positive cells appearing in the periodontal ligament space on the pressure side of the alveolar bone were increased markedly in experimental group. There were statistically significant differences in the amount of osteoclasts between experimental and control groups (P<0.01).Local injection of rhTGF-β1 in the periodontal tissues can accelerate orthodontic tooth movement via enhancing the numbers of osteoclasts. At the histologic level, increased numbers of mononuclear osteoclasts are recruited and activated, resulting in greater amounts of alveolar bone resorption on the pressure side of the periodontal ligament." @default.
- W2368452469 created "2016-06-24" @default.
- W2368452469 creator A5006106256 @default.
- W2368452469 creator A5010491128 @default.
- W2368452469 creator A5045707097 @default.
- W2368452469 creator A5053571254 @default.
- W2368452469 date "2014-08-01" @default.
- W2368452469 modified "2023-09-26" @default.
- W2368452469 title "[Effect of local injection of rhTGF-α1 on osteoclasts during orthodontic tooth movement in rats]." @default.
- W2368452469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25338791" @default.
- W2368452469 hasPublicationYear "2014" @default.
- W2368452469 type Work @default.
- W2368452469 sameAs 2368452469 @default.
- W2368452469 citedByCount "0" @default.
- W2368452469 crossrefType "journal-article" @default.
- W2368452469 hasAuthorship W2368452469A5006106256 @default.
- W2368452469 hasAuthorship W2368452469A5010491128 @default.
- W2368452469 hasAuthorship W2368452469A5045707097 @default.
- W2368452469 hasAuthorship W2368452469A5053571254 @default.
- W2368452469 hasConcept C181199279 @default.
- W2368452469 hasConcept C185592680 @default.
- W2368452469 hasConcept C195735259 @default.
- W2368452469 hasConcept C199343813 @default.
- W2368452469 hasConcept C202271784 @default.
- W2368452469 hasConcept C21547065 @default.
- W2368452469 hasConcept C2778812414 @default.
- W2368452469 hasConcept C2780579991 @default.
- W2368452469 hasConcept C29694066 @default.
- W2368452469 hasConcept C55493867 @default.
- W2368452469 hasConcept C62836269 @default.
- W2368452469 hasConcept C71924100 @default.
- W2368452469 hasConcept C73753567 @default.
- W2368452469 hasConceptScore W2368452469C181199279 @default.
- W2368452469 hasConceptScore W2368452469C185592680 @default.
- W2368452469 hasConceptScore W2368452469C195735259 @default.
- W2368452469 hasConceptScore W2368452469C199343813 @default.
- W2368452469 hasConceptScore W2368452469C202271784 @default.
- W2368452469 hasConceptScore W2368452469C21547065 @default.
- W2368452469 hasConceptScore W2368452469C2778812414 @default.
- W2368452469 hasConceptScore W2368452469C2780579991 @default.
- W2368452469 hasConceptScore W2368452469C29694066 @default.
- W2368452469 hasConceptScore W2368452469C55493867 @default.
- W2368452469 hasConceptScore W2368452469C62836269 @default.
- W2368452469 hasConceptScore W2368452469C71924100 @default.
- W2368452469 hasConceptScore W2368452469C73753567 @default.
- W2368452469 hasIssue "4" @default.
- W2368452469 hasLocation W23684524691 @default.
- W2368452469 hasOpenAccess W2368452469 @default.
- W2368452469 hasPrimaryLocation W23684524691 @default.
- W2368452469 hasRelatedWork W1998646101 @default.
- W2368452469 hasRelatedWork W2166446951 @default.
- W2368452469 hasRelatedWork W2280016356 @default.
- W2368452469 hasRelatedWork W2368452469 @default.
- W2368452469 hasRelatedWork W2383222075 @default.
- W2368452469 hasRelatedWork W2743957342 @default.
- W2368452469 hasRelatedWork W3133370663 @default.
- W2368452469 hasRelatedWork W3150230636 @default.
- W2368452469 hasRelatedWork W4284701655 @default.
- W2368452469 hasRelatedWork W2182555658 @default.
- W2368452469 hasVolume "23" @default.
- W2368452469 isParatext "false" @default.
- W2368452469 isRetracted "false" @default.
- W2368452469 magId "2368452469" @default.
- W2368452469 workType "article" @default.