Matches in SemOpenAlex for { <https://semopenalex.org/work/W2368458144> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2368458144 abstract "Despite the varied approaches to the pain syndrome therapy with the changes and improvements of evolutionary medicine’s development and the drugs which are used to treat pain there are still considerable difficulties in solving this problem.Aim. To detect compounds that are able to change the pain in experimental animals the action of salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-ylthio)acetic acid on central component of the nociceptive system has been studied in terms of thermal irritation of the extremities of rats.Materials and results. First synthesized salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3- ylthio)acetic acid have been used in studies. Analgesic activity has been determined on «a hot plate» model, based on the ability of studied substances to change the pain threshold of experimental animals in comparison with control and expressed in percents. Analgin was used as the comparison drug at a dose of 1000 mg/kg (Analgin-Darnitsa, solution for injections, 500 mg/ml, 2 ml in ampules № 10).Conclusions. The regularities between chemical structure and pharmacological action of 1,2,4-triazole derivatives have been determined. It testifies the prospects of further studies of salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-ylthio)acetic acid, as potential substances to create new drugs." @default.
- W2368458144 created "2016-06-24" @default.
- W2368458144 creator A5054387718 @default.
- W2368458144 date "2016-03-09" @default.
- W2368458144 modified "2023-09-27" @default.
- W2368458144 title "Analgesic activity of the salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-ylthio)acetic acid" @default.
- W2368458144 cites W2144457757 @default.
- W2368458144 doi "https://doi.org/10.14739/2409-2932.2016.1.61105" @default.
- W2368458144 hasPublicationYear "2016" @default.
- W2368458144 type Work @default.
- W2368458144 sameAs 2368458144 @default.
- W2368458144 citedByCount "0" @default.
- W2368458144 crossrefType "journal-article" @default.
- W2368458144 hasAuthorship W2368458144A5054387718 @default.
- W2368458144 hasBestOaLocation W23684581441 @default.
- W2368458144 hasConcept C13965031 @default.
- W2368458144 hasConcept C155647269 @default.
- W2368458144 hasConcept C178790620 @default.
- W2368458144 hasConcept C185592680 @default.
- W2368458144 hasConcept C203014093 @default.
- W2368458144 hasConcept C2776673659 @default.
- W2368458144 hasConcept C2777063393 @default.
- W2368458144 hasConcept C2777907353 @default.
- W2368458144 hasConcept C2779556047 @default.
- W2368458144 hasConcept C2780020378 @default.
- W2368458144 hasConcept C2780820201 @default.
- W2368458144 hasConcept C71240020 @default.
- W2368458144 hasConcept C71924100 @default.
- W2368458144 hasConcept C98274493 @default.
- W2368458144 hasConceptScore W2368458144C13965031 @default.
- W2368458144 hasConceptScore W2368458144C155647269 @default.
- W2368458144 hasConceptScore W2368458144C178790620 @default.
- W2368458144 hasConceptScore W2368458144C185592680 @default.
- W2368458144 hasConceptScore W2368458144C203014093 @default.
- W2368458144 hasConceptScore W2368458144C2776673659 @default.
- W2368458144 hasConceptScore W2368458144C2777063393 @default.
- W2368458144 hasConceptScore W2368458144C2777907353 @default.
- W2368458144 hasConceptScore W2368458144C2779556047 @default.
- W2368458144 hasConceptScore W2368458144C2780020378 @default.
- W2368458144 hasConceptScore W2368458144C2780820201 @default.
- W2368458144 hasConceptScore W2368458144C71240020 @default.
- W2368458144 hasConceptScore W2368458144C71924100 @default.
- W2368458144 hasConceptScore W2368458144C98274493 @default.
- W2368458144 hasIssue "1" @default.
- W2368458144 hasLocation W23684581441 @default.
- W2368458144 hasLocation W23684581442 @default.
- W2368458144 hasOpenAccess W2368458144 @default.
- W2368458144 hasPrimaryLocation W23684581441 @default.
- W2368458144 hasRelatedWork W1998194504 @default.
- W2368458144 hasRelatedWork W2024884191 @default.
- W2368458144 hasRelatedWork W2039590858 @default.
- W2368458144 hasRelatedWork W2104324630 @default.
- W2368458144 hasRelatedWork W2141757030 @default.
- W2368458144 hasRelatedWork W2368458144 @default.
- W2368458144 hasRelatedWork W2377610424 @default.
- W2368458144 hasRelatedWork W2412697918 @default.
- W2368458144 hasRelatedWork W2950147262 @default.
- W2368458144 hasRelatedWork W2951175711 @default.
- W2368458144 hasVolume "0" @default.
- W2368458144 isParatext "false" @default.
- W2368458144 isRetracted "false" @default.
- W2368458144 magId "2368458144" @default.
- W2368458144 workType "article" @default.