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- W2368458275 abstract "Objectives To investigate the regulation role of endocannabinoid in heat stress response and its possible receptor signaling pathway.Methods Rat glioma C6 cells were pretreated with different concentrations(10-7,10-6 and 10-5mol/L)of endocannabinoid 2-Arachidonylglycerol(2-AG)for 1 h,then heat stress(42 ℃ water bath)was performed for 1 h.Reverse transcription-PCR and Western blotting were used to detect the expression levels of HSP70 mRNA and protein.The blockade effects of selective CB1 antagonist AM251(10-4 mol/L)or CB2 antagonist AM630(10-4 mol/L)were also observed by adding them to the culture medium when 2-AG was pretreated.Results The expression levels of HSP70 mRNA and protein in heat stressed C6 cells were significantly increased after 2-AG treatment.This enhancement was mainly through CB1 receptor signaling pathway.Conclusion Certain level of 2-AG significantly promotes the expression of HSP70 gene post heat stress,suggesting that 2-AG is involved in the regulation of heat stress response.The promotion effect of 2-AG in C6 cells is mainly mediated through CB1 receptor signaling pathway,but not CB2." @default.
- W2368458275 created "2016-06-24" @default.
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- W2368458275 date "2009-01-01" @default.
- W2368458275 modified "2023-09-24" @default.
- W2368458275 title "Endocannabinoid 2-AG enhances HSP70 gene expression in heat stress response in vitro" @default.
- W2368458275 hasPublicationYear "2009" @default.
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