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- W2368520132 abstract "To develop an animal model that closely mimics human food allergy, 4 groups of BN rats were given one of the following substances by gavage dairly for 42 days: Ovalbumin(1mg in 1ml), Potato acid phosphatase (1 mg in 1 ml), hens egg white protein (10 mg in 1 ml) and sterile water(1 ml).The serum levers of specific IgE antibodies were measured on the 14th, 28th and 42nd day by enzyme linked immunosorbent assay and passive cutaneous anaphylaxis assay. In OVA and HEWP groups,significantly high titres of specific IgE (1∶32) were provoked compared with that in the control group at the 28th and 42nd day. However, at the 14th, 28th, and 42nd day in PAP group and at the 14th day in OVA and HEWP groups, the difference of specific IgE between test groups and the control group was not significant. BN rats could be made allergic to OVA and HEWP(major allergenic protein), and could not be made allergic to PAP( non allergenic protein). It is concluded that BN rats may be a fairly good animal model suitable for the investigation of food allergy." @default.
- W2368520132 created "2016-06-24" @default.
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- W2368520132 date "2005-01-01" @default.
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- W2368520132 title "Assessment of brown Norway rat as suitable animal model for investigation of food allergy" @default.
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