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- W2368528022 abstract "In anesthetized rats, berberine (Ber) 20 mg / kg, iv increased the cardiac index and stroke volume index. In the isolated guinea pig left atria, Ber 0.1 μmol/L shifted the dose-response curve of ouabain (Oua) to the left with the increase of the maximal effect. Ber 10 and 30 μmol / L potentiated the maximal contractile force of Oua and diminished the dose with which Oua caused the peak effect. Ber 30 and 100 μmol/L elevated the dose in which the toxicity of Oua occurred. The influence of hypoxia on the positive inotropic effect of Ber was not obvious. Above results suggested that Ber might increase the cardiac output and widen the margin of safty with ouabain-treatment." @default.
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- W2368528022 date "1991-01-01" @default.
- W2368528022 modified "2023-09-24" @default.
- W2368528022 title "Influence of berberine on rat cardiac output and on the effect of ouabain in guinea pig left atria" @default.
- W2368528022 hasPublicationYear "1991" @default.
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