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- W2368549326 abstract "Objective To investigate the effect of Xingnaojing(xnjj) on the apoptosis of hippocampal neurons in rats with subarachnoid hemorrhage(SAH).Methods The SAH model was established by two time autologous blood injection into the cisterna magna of adult male Wistar rats.35 rats were randomly divided into 5 groups naive,saline control,SAH,xnjj treatment 1,and xnjj treatment 2 groups.Gene expressions of Caspase-3,Bax,and Bcl-2 in different groups after SAH were detected with Real-Time PCR.Further,Western blot was applied to determine protein changes of these three molecules after SAH.Results Compared with the control group,Caspase-3,Bax,and Bcl-2 increased in varying degrees in the hippocampus of the SAH group(P0.05),while in Xingnaojing treatment groups,Caspase-3 and Bax,but not Bcl-2,decreased when compared with the SAH group(P0.01).Conclusion Xingnaojing shows an obvious neuroprotective effect on hippocampal neurons by inhibiting SAH-related apoptosis." @default.
- W2368549326 created "2016-06-24" @default.
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- W2368549326 date "2011-01-01" @default.
- W2368549326 modified "2023-09-23" @default.
- W2368549326 title "Effect of Xingnaojing on apoptosis of hippocampal neurons in rats with subarachnoid hemorrhage" @default.
- W2368549326 hasPublicationYear "2011" @default.
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