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- W2368557949 abstract "Objective:To observe the effects of inactivated SARS virus on the mucosal immune system in BALB/c mice by intramuscular injection during the early stage in mice. Methods:Five week_old female BALB/c mice were randomly divided into two groups, five mice per group. Each mouse of the experiment group was intramuscularly injected with a single dose of 50?μg of the inactivated SARS virus in 100?μl PBS without any adjuvant, the control ones were injected into the equal volume of PBS. Then all mice were sacrificed on the third day, and the lymphocyte phenotypes from different mucosal tissues were detected by FACS.Results:After intramuscular injection with inactivated SARS virus, the fluorescent intensity of CD + 4 T cell in nasal mucosa associated lymphatic tissue (NALT) strengthen significantly( P 0.05) on the third day, and that of CD + 3 T cell in NALT tended to increase ( P =0.052). The CD + 4 and CD + 8 T cells in nasal passage (NP) increased significantly( P 0.05) than that of control ones. Both the CD + 3T and the ratio of T/ B in NP had an increased trend, whereas the fluorescent intensity of CD + 4,CD + 3T and B cells in NP strengthen significantly than that of the control mice ( P 0.05). In the lung, CD + 8T cells decreased significantly( P 0.05) , but B cells increased significantly ( P 0.01). The CD + 4 T and the ratio of T/ B from lung had a decreased trend, whereas the ratio of CD + 4/CD + 8 tended to increase. Not only the fluorescent intensities of CD + 3T cells in lung enhanced ( P 0.05), but also the CD + 4T cells in lung had an increased trend ( P =0.086). On the other hand, B cells in Peyer′s patches(PP) increased significantly ( P 0.05) than that of control mice.Conclusions:The lymphocyte phenotype from different mucosal tissues of BALB/c mice changed after intramuscular injection with inactivated SARS virus on day 3, suggesting that the inactivated SARS virus could induce mucosal immune response in the intramuscularly injected mice." @default.
- W2368557949 created "2016-06-24" @default.
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- W2368557949 date "2003-01-01" @default.
- W2368557949 modified "2023-09-25" @default.
- W2368557949 title "Effect of inactivated SARS virus on the lymphocyte phenotypes from different mucosal tissues in BALB/c mice by intramuscular injection during the early stage" @default.
- W2368557949 hasPublicationYear "2003" @default.
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