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- W2368580849 abstract "Objective: To investigate the effect of P53 protein on telomerase activity in human keloid fibroblasts. Method: Fibroblasts derived from keloid tissue were transfected by adenovirus - wt - P53 gene. The expression of P53 protein was checked by immunofluorescence. The activity of telomerase was checked by TRAP - ELISA and compared with that of fibroblasts not transfected by adenovirus - wt - P53 gene. Result: In fibroblasts transfected by adenovirus - wt - P53 gene, the expression of P53 protein was higher and the telomerase activity was lower than that in not transfected fibroblasts ( P 0.01). Conclusion: P53 protein significantly inhibits telomerase activity in human keloid fibroblasts." @default.
- W2368580849 created "2016-06-24" @default.
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- W2368580849 date "2006-01-01" @default.
- W2368580849 modified "2023-09-25" @default.
- W2368580849 title "Experimental research on the effect of P_(53) protein on telomerase activity in human keloid fibroblasts" @default.
- W2368580849 hasPublicationYear "2006" @default.
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