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- W2368581632 abstract "Objective Antioxidant stress helps the treatment of diabetic nephropathy(DN),but the action mechanism of alprostadil as a conventional antioxidant remains unclear.This study is to observe the effect of alprostadil on oxidative damage in type-2 DN patients.Methods Totally 61 DN patients were divided into a routine therapy group(n = 30) and an alprostadil group(n = 31).The level of 8-hydroxy-desoxyguanosine(8-OHdG) was determined before and after 10 days of medication,and meanwhile it was also measured in another 65 healthy subjects(normal control group).Results Before treatment,the level of 8-OHdG in the DN patients was(3.48 ± 1.86) ng / ml,significantly higher than(0.72 ± 0.93) ng / ml in the normal control group(P 0.001).After 10 days of medication,the 8-OHdG level showed no significant change in the routine therapy group,but markedly decreased in the alprostadil group,with statistically significant difference between the two groups(P 0.01).Conclusion Alprostadil has a significant antioxidant stress effect in type 2 diabetic patients with nephropathy." @default.
- W2368581632 created "2016-06-24" @default.
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- W2368581632 date "2013-01-01" @default.
- W2368581632 modified "2023-09-25" @default.
- W2368581632 title "Effect of alprostadil on oxidative damage in type 2 diabetic nephropathy" @default.
- W2368581632 hasPublicationYear "2013" @default.
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