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- W2368585566 abstract "Objective To investigate the feasibility of PNIPAM as an embolic agent for the treatment of cerebral arteriovenous malformations.Methods The PNIPAM was synthesized and mixed with iohexol.The mixture was examined biologically and used for RMB embolization in 36 domestic swine.Follow-up angiography was performed to observe the efficacy of embolization.Embolized RMBs were examined histopatholgically,the alterations of tissue inside RMB and surrounding were observed.Results The PNIPAM mixture was conformed to the relevant standard.34 swine survived the embolization,while 2 died.The inside wall of the microcatheter was smooth and there was no copolymer adhered to the wall.Follow-up angiography of 24 swine showed that there was no RMB recanalization in 21 swine and partial RMB recanalization in 3 swine(because of the trunk embolization of ascending pharyngeal arteries).The copolymer was found diffused to vessels with the diameter of 100~200 μm.Conclusion The copolymer hydrogel has optimized characteristics including embolic instability,better biocompatibility,radiopacity,non-adhesiveness,compatibility to general microcatheters.It can be used for endovascular treatment of cerebral arteriovenous malformations." @default.
- W2368585566 created "2016-06-24" @default.
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- W2368585566 date "2008-01-01" @default.
- W2368585566 modified "2023-09-24" @default.
- W2368585566 title "Feasibility of thermosensitive embolic agent for the treatment of cerebral arteriovenous malformations" @default.
- W2368585566 hasPublicationYear "2008" @default.
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