Matches in SemOpenAlex for { <https://semopenalex.org/work/W2368596189> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2368596189 endingPage "8" @default.
- W2368596189 startingPage "253" @default.
- W2368596189 abstract "Simian immunodeficiency virus from sooty mangabey monkeys (SIVsmm), a lentivirus closely related to SIV from macaques and the human immunodeficiency virus type 2 (HIV-2), is pathogenic for various species of macaques but is nonpathogenic for mangabeys. Comparison of in vivo and in vitro responses of macaques and mangabeys or their lymphocytes, respectively, to SIVsmm infection indicated that lack of disease in mangabeys apparently was not due to effective control of virus expression by the immune system because SIVsmm-infected, asymptomatic mangabeys have high viral loads. Failure of mangabeys to develop disease may be related to the fact that the prototype SIVsmm (SMM-9) replicated in, but was not cytopathic for, mangabey CD4+ cells. In contrast, replication of SMM-9 in peripheral blood mononuclear cells from pigtailed macaques resulted in specific loss of CD4+ cells and induction of an AIDS-like disease. A variant of SMM-9, designated SMM-PBj14, was identified, however, that was extremely cytopathic for mangabey CD4+ cells and also induced acute lethal disease in both macaques and mangabeys. Acute disease was associated with extensive lymphoid hyperplasia, which was correlated in vitro with induction of proliferation of PBMC in SMM-PBj14-infected cultures. Infectious molecular clones of SMM-PBj14 exhibited the same in vitro and in vivo properties as SMM-PBj14. Future analysis of chimeric viruses may lead to the identification of specific regions of the viral genome that influence the various in vivo and in vitro properties of these SIVsmm isolates." @default.
- W2368596189 created "2016-06-24" @default.
- W2368596189 creator A5028336562 @default.
- W2368596189 creator A5061121047 @default.
- W2368596189 creator A5081761664 @default.
- W2368596189 creator A5087386559 @default.
- W2368596189 creator A5090911936 @default.
- W2368596189 date "1990-01-01" @default.
- W2368596189 modified "2023-09-23" @default.
- W2368596189 title "SIVsmm infection of macaque and mangabey monkeys: correlation between in vivo and in vitro properties of different isolates." @default.
- W2368596189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1980901" @default.
- W2368596189 hasPublicationYear "1990" @default.
- W2368596189 type Work @default.
- W2368596189 sameAs 2368596189 @default.
- W2368596189 citedByCount "13" @default.
- W2368596189 crossrefType "journal-article" @default.
- W2368596189 hasAuthorship W2368596189A5028336562 @default.
- W2368596189 hasAuthorship W2368596189A5061121047 @default.
- W2368596189 hasAuthorship W2368596189A5081761664 @default.
- W2368596189 hasAuthorship W2368596189A5087386559 @default.
- W2368596189 hasAuthorship W2368596189A5090911936 @default.
- W2368596189 hasConcept C137061746 @default.
- W2368596189 hasConcept C151730666 @default.
- W2368596189 hasConcept C159047783 @default.
- W2368596189 hasConcept C202751555 @default.
- W2368596189 hasConcept C203014093 @default.
- W2368596189 hasConcept C207001950 @default.
- W2368596189 hasConcept C2522874641 @default.
- W2368596189 hasConcept C2775996393 @default.
- W2368596189 hasConcept C2777995582 @default.
- W2368596189 hasConcept C2778950215 @default.
- W2368596189 hasConcept C2779690655 @default.
- W2368596189 hasConcept C2780727368 @default.
- W2368596189 hasConcept C54355233 @default.
- W2368596189 hasConcept C86803240 @default.
- W2368596189 hasConcept C8891405 @default.
- W2368596189 hasConceptScore W2368596189C137061746 @default.
- W2368596189 hasConceptScore W2368596189C151730666 @default.
- W2368596189 hasConceptScore W2368596189C159047783 @default.
- W2368596189 hasConceptScore W2368596189C202751555 @default.
- W2368596189 hasConceptScore W2368596189C203014093 @default.
- W2368596189 hasConceptScore W2368596189C207001950 @default.
- W2368596189 hasConceptScore W2368596189C2522874641 @default.
- W2368596189 hasConceptScore W2368596189C2775996393 @default.
- W2368596189 hasConceptScore W2368596189C2777995582 @default.
- W2368596189 hasConceptScore W2368596189C2778950215 @default.
- W2368596189 hasConceptScore W2368596189C2779690655 @default.
- W2368596189 hasConceptScore W2368596189C2780727368 @default.
- W2368596189 hasConceptScore W2368596189C54355233 @default.
- W2368596189 hasConceptScore W2368596189C86803240 @default.
- W2368596189 hasConceptScore W2368596189C8891405 @default.
- W2368596189 hasLocation W23685961891 @default.
- W2368596189 hasOpenAccess W2368596189 @default.
- W2368596189 hasPrimaryLocation W23685961891 @default.
- W2368596189 hasRelatedWork W1531068485 @default.
- W2368596189 hasRelatedWork W1807332226 @default.
- W2368596189 hasRelatedWork W1820808323 @default.
- W2368596189 hasRelatedWork W2003241690 @default.
- W2368596189 hasRelatedWork W2006233149 @default.
- W2368596189 hasRelatedWork W2056473717 @default.
- W2368596189 hasRelatedWork W2084078776 @default.
- W2368596189 hasRelatedWork W2090251528 @default.
- W2368596189 hasRelatedWork W2119739349 @default.
- W2368596189 hasRelatedWork W2156731171 @default.
- W2368596189 hasVolume "72" @default.
- W2368596189 isParatext "false" @default.
- W2368596189 isRetracted "false" @default.
- W2368596189 magId "2368596189" @default.
- W2368596189 workType "article" @default.