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- W2368596306 abstract "Objective To investigate the expression and significance of sCD40 ligand(sCD40L) in large artery atherosclerosis(LAA). Methods Plasma levels of sCD40L,granule membrane protein 140(GMP-140) and interleukin-6(IL-6) were measured using ELISA in 29 patients with LAA(group A) and 11 healthy controls(group B). Results GMP-140 was higher in group A than that in group B [(43.78±16.61)ng/ml vs.(9.42±2.96)ng/ml](P0.01).So did plasma sCD40L [(8.36±4.30)ng/ml vs.(3.52±1.69)ng/ml] and IL-6 [(55.59±18.20)pg/ml vs.(30.33± 7.45)pg/ml](P0.01).A positive linear correlation was seen between sCD40L and GMP-140,sCD40L and IL-6,GMP-140 and IL-6. Conclusion The results indicate that platelet-derived CD40L may be an important mediator for inflammation,atherosclerosis plaque destabilization and thrombosis in LAA patients.The upregulation of sCD40L in circulation may be taken as a marker showing platelet activation and development of unestable atherosclerosis plaque to ischemic stroke." @default.
- W2368596306 created "2016-06-24" @default.
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- W2368596306 date "2011-01-01" @default.
- W2368596306 modified "2023-09-28" @default.
- W2368596306 title "Expression and significance of sCD40 ligand in large artery atherosclerosis" @default.
- W2368596306 hasPublicationYear "2011" @default.
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