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- W2368596483 abstract "ObjectiveTo investigate expression of intercellular adhesion molecule-1 and neuronal damage after diffuse brain injury in rats. MethodsReal-time quantitative PCR, immunohistochemistry, histological techniques and electron microscopic were used to determine expression of ICAM-1 and its mRNA and neuronal damage in the different time after diffuse brain injury in rats. ResultsContrasted to sham-operated group(positive microvessles number, 0.4±0.5),the expression of ICAM-1 started increase at the 6th h evidently(4.8±0.8), peaked at the 72th h (17.2±2.4)respectively(P0.05). Its mRNA increased at the third h (△Ct :13.48±3.93)evidently, peaked at the 72th h(20.59±0.97) and the level at 7d (15.60±0.01)were higher than sham-operated group(4.66±1.11)(P0.01). Neurons were denaturalization, edema and necrosis diffusely, distinctly at the 72th h under light microscopic and electron microscopic. ConclusionThe expression of ICAM-1 is increased after diffuse brain injury in rats, which participates in the adhesion between neutrophils and capillary endothelial cells. This indicates that ICAM-1 closely associated with inflammatory reaction and neuronal damage." @default.
- W2368596483 created "2016-06-24" @default.
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- W2368596483 date "2006-01-01" @default.
- W2368596483 modified "2023-09-22" @default.
- W2368596483 title "Expression of intercellular adhesion molecule-1 and neuronal damage after diffuse brain injury in rats" @default.
- W2368596483 hasPublicationYear "2006" @default.
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