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- W2368607514 abstract "A method of ketoconazole resistance screening was applied to breed mutants with high hydrocortisone transformation. The protoplast of Curvularia lunata, treated with UV light were regenerated on agar plates containing 10 μmol/L ketoconazole and 136 ketoconazole resistance mutants were obtained. The hydrocortisone conversion rates of 14 mutants were higher than that of the original strain. Among them, the hydrocortisone conversion rate of KA-91 was 42% higher than that of the original strain and reached 68.05%. The medium and fermentation conditions of KA-91 were optimized. Under the optimum condition, the hydrocortisone conversion rate reached 73.6%. Fig 7, Tab 3, Ref 5" @default.
- W2368607514 created "2016-06-24" @default.
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- W2368607514 date "2004-01-01" @default.
- W2368607514 modified "2023-09-23" @default.
- W2368607514 title "BREEDING OF HIGH HYDROCORTISONE TRANSFORMING STRAINS AND THEIR OPTIMAL FERMENTATION CONDITIONS" @default.
- W2368607514 hasPublicationYear "2004" @default.
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