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- W2368617372 abstract "Objective:To explore the mechanism of resistance of gastric cancer to Paclitaxel,this study is designed to establish a Paclitaxel-induced human gastric cancer drug-resistant cell line and study its changes of resistance.Methods:A resistant gastric cancer cell line(MGC803/PA) each month maked the correlation detection;drug sensitivity was detected by MTT assay;the changes of its biological characteristics were determined by using light microscopy,electron microscopy,cell counting by MTT assay.Results:MGC803/PA cell line was developed after 4 months with stable resistance to Paclitaxel and each month(2、3、4 month) the resistance index was 5.12,11.46,15.98;MGC803/PA cell exhibited cross-resistance to other chemotherapeutic agents.The morphology of MGC803/PA gradually changed.Conclusion:MGC803/PA cells line shows the typical and stable resistant phenotype,multiplication of MGC803/PA cell line gradually decreased,MTT assay and electron microscopy early prompts resistance of MGC803/PA cell line." @default.
- W2368617372 created "2016-06-24" @default.
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- W2368617372 date "2011-01-01" @default.
- W2368617372 modified "2023-09-26" @default.
- W2368617372 title "Study of building of a Paclitaxel-induced human gastric cancer drug-resistant cell line" @default.
- W2368617372 hasPublicationYear "2011" @default.
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