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- W2368643306 abstract "Subcutaneous injection of crude peanut protein was used to establish a peanut allergy model of Balb/c mice,and based on the model,the corresponding pathogenesis of food allergy was explored.Sixteen(female) Balb/c mice were divided into two groups:a control group and a peanut allergy model group.Intestinal inflammation was analyzed by haematoxylin and eosin(HE) staining and TEM.Compared with the control group,the intestinal mucosal edema and infiltration of inflammatory cells were observed in the allergy model group.In addition,the damaged microvilli were observed under TEM in intestinal villi.Permeation of blood vessel was investigated by injecting Evans blue through caudal vein.The blue claws appeared in the allergy model group after the injection of Evans blue.The results of peritoneal lavaging experiment showed increased number of inflammatory cells including eosinophils,lymphocytes and mast cells and significant activation of mast cells in the allergy model group compared with the PBS group.The serumal levels of IgE,IL-4,IL-5,IL-6 and histamine as well as histamine level in peritoneal lavage fluid were significantly higher than those accordingly in the PBS group that were assayed by enzyme-linked immunoassay(ELISA).On the other hand,significantly decreased IgG2a,IFN-γ were detected in the allergy model group compared with those in the PBS group.In conclusion,a successful mice allergy model to peanut is established,in the model a series of pathologic changes of allergy are observed,and based on the model the pathogenesis and immunotherapy of peanut allergen induced hypersensitivity can be explored." @default.
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- W2368643306 date "2012-01-01" @default.
- W2368643306 modified "2023-09-23" @default.
- W2368643306 title "Establishment and pathogenesis of mouse peanut allergy model" @default.
- W2368643306 hasPublicationYear "2012" @default.
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