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- W2368652675 abstract "[Objective] To investigate the effect of all-trans retinoic acid on production of MIP-2 of lungs in rats with chronic obstructive pulmonary diseases(COPD).[Methods] Twenty two rats were randomly divided into model,retinoid acid treatment or control groups(n=8).The rats were inhaled with tobacco smoke every day for 28 days and instilled intratracheally with E.coli lipopolysaccharide(lipopolysaccharide,LPS) on day 1st and 14 th with all-trans retinoic acid gavages(ATRA group) or not treated(model group).Normal rats were used to control group.On day 28 th all of rats were sacrificed.Their lungs were used to morphological observation changes and tissue homogenate.The content of MIP-2 was measured with ELISA.Activity of Myeloperoxidase(MPO) was measured with colorimetric method.[Results]The diameter of alveoli of the rats treated with all-trans retinoic acid was decreased,the number of alveoli each field of microscope was increased.In ATRA and COPD modle groups,the MIP contents were(16.62±6.03)pg/mL and(41.43±7.36)pg/mL,the MPO activities were(9.13±2.15)U/g and(12.2±1.72)U/g.[Conclusion]Inhibiting the production and function of neutrophils may be one of mechanism by which all-trans retinoic acid treat COPD." @default.
- W2368652675 created "2016-06-24" @default.
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- W2368652675 date "2009-01-01" @default.
- W2368652675 modified "2023-09-26" @default.
- W2368652675 title "Effects of All-trans retinoic acid on production of MIP-2 of lungs in rats with chronic obstructive pulmonary diseases" @default.
- W2368652675 hasPublicationYear "2009" @default.
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