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- W2368655032 abstract "Objective To understand the significance of expressions of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in colorectal cancer.Methods Fifty colorectal cancer speciments from patients were used in the study,pathological examination had proved 15 as well differentiated adenocarcinoma,15 as poorly differentiated adenocercinoma,and 20 as undifferentiated carcinoma;metastatic colorectal cancer 30 cases,unmetastatic 20 cases.Detections were made by immunohistochemical staining.Results A close relationship of MMP9,MMP2 (members of MMPs) with colorectal cancer′s invasion metastasis was observed.The positive expression rate of MMP9,MMP2 in the lymphatic metastasis group was obviously higher than that in the group without lymphatic metastasis;the above rate was also higher in undifferentiated cancer group or in poorly differentiated adenocarcinoma group than in well differentiated adenocarcinoma group.The positive expression rate of TIMP 1,TIMP 2 (members of TIMPs) in lymphatic metastasis group was markedly lower than that in the group without metastasis.Conclusion The study points out that MMP9,MMP2 and TIMP 1,TIMP 2 play an important role in the following process-colorectal cancer cells breaking into basement membrane to make a diffusional transfer to the lymph nodes.Both MMPs and TIMPs involve in the metastatic process of colorectal cancer." @default.
- W2368655032 created "2016-06-24" @default.
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- W2368655032 date "2002-01-01" @default.
- W2368655032 modified "2023-09-24" @default.
- W2368655032 title "A study on the roles of matrix metalloproteinases and tissue inhibitor of metalloproteinases in the invasion-metastasis of colorectal cancer" @default.
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