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- W2368656154 abstract "Objective To investigate the relationship between insulin resistance and liver fibrosis markers in the patients with hepatogenic diabetes(HD) caused by chronic hepatitis B and liver fibrosis. Methods 76patients with chronic hepatitis B were selected into group A, 86 patients with liver cirrhosis of HBV were selected into group B. Biochemical assay was used to determine body weight, height, liver-function, HBsAg, HBeAg,glucose and lipid metabolism, liver fibrosis markers, hemoglobin, fasting insulin, fasting glucose and posting glucose. Body mass index and index of insulin resistance(HOMA-IR) were calculated. Results 65 patients with HD, the incidence of HD in group B patients(50.0%) was significantly higher compared with group A(28.9%)(P 0.01). PC-III is the independent risk factor of insulin resistance(IR) occurrence in the patients with chronic hepatitis B and liver fibrosis. Hyaluronic acid(HA) and HBeAg-positive patients are risk factors of liver cirrhosis patients with IR. In HD patients, laminin(LN) and IV collagen(IV-C) were significantly positively related to PPG(P 0.010). Conclusions In patients with chronic hepatitis B, liver fibrosis promote the development of IR, and eventually lead to occurrence of HD. Meanwhile, high blood sugar can also be involved in promoting cirrhosis occurrence and development, and further aggravate liver injury." @default.
- W2368656154 created "2016-06-24" @default.
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- W2368656154 date "2013-01-01" @default.
- W2368656154 modified "2023-09-26" @default.
- W2368656154 title "Analysis of the relationship between insulin resistance and liver fibrosis markers in the patients with hepatogenic diabetes caused by chronic hepatitis B and liver cirrhosis" @default.
- W2368656154 hasPublicationYear "2013" @default.
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