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- W2368657100 abstract "Objective To study the expressions of co stimulatory factors CD28 and CTLA 4 on CD3 + T cells in peripheral blood lymphocytes (PBMC) and synovial fluid lymphocytes (SFMC) in patients with rheumatoid arthritis (RA) and the relationship of these molecules with the activity of RA. Methods The lymphocytes were collected from the peripheral blood and synovial fluid in RA patients. The CD3 +CD28 + and CD3 +CTLA 4 + molecules on these cells were measured by dual color fluorescence cytometry. The correlation of the expressions of CD3+CD28+ and CD3 +CTLA 4 + molecules with the activity of RA was statistically analyzed by Spearman. Results ① The level of CD3 +CD28 + in PBMC of RA patients was significantly lower than that of the control group and SFMC ( P 0 01). ② The expression of CD3 +CTLA 4 + in PBMC was not significantly different from that of the control group, but lower than that of SFMC ( P 0.05). ③ The expression of CD3 +CD28 + in SFMC of RA patients was not significantly different from that of control group, but the expression of CD3 +CTLA 4 + was significantly higher than that of the control group ( P 0 01). ④ The expressions of CD28 and CTLA 4 were partly associated with the activity of RA. Conclusion The abnormal expression of CD28 and CTLA 4 molecules in peripheral blood lymphocytes and synovial fluid lymphocytes is one of the important mechanisms involved in the genesis and progression of RA, but the definite roles in the process of the disease are not clear." @default.
- W2368657100 created "2016-06-24" @default.
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- W2368657100 date "2004-01-01" @default.
- W2368657100 modified "2023-09-25" @default.
- W2368657100 title "Expressions of CD28 and CTLA-4 in peripheral blood and synovial fluid lymphocytes in patients with rheumatoid arthritis and the significance" @default.
- W2368657100 hasPublicationYear "2004" @default.
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